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side view shot of sliced beef brisket
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4.59 from 17 votes

Beef Brisket Gyros

These Beef Brisket Gyros are loaded with Mediterranean flavors, super quick to prepare and totally delicious. Cook the Beef Brisket in your oven, slow cooker or Instant Pot, but the end result is always the same. Tender, juicy, fall apart in your mouth beef!
Prep Time10 minutes
Cook Time4 hours 10 minutes
Total Time4 hours 20 minutes
Course: Main Course
Cuisine: Greek
Keyword: beef, brisket, gyros
Servings: 8
Calories: 562kcal
Author: Joanna Cismaru

Ingredients

Beef Brisket

  • 4 pound beef brisket
  • 2 tablespoon olive oil
  • 1 cup beef broth low sodium

Dry Rub

  • 1 teaspoon oregano dried
  • 1 tablespoon dill dried
  • 1 teaspoon Italian seasoning
  • 1 teaspoon garlic powder
  • ½ teaspoon salt or to taste
  • 1 teaspoon black pepper or to taste

Gyros

US Customary - Metric

Instructions

  • Preheat your oven to 325℉.
  • Add all the dry rub ingredients to a small bowl and stir to combine.
  • Rub the dry rub all over the brisket on both sides, using your hands. 
  • Add the olive oil to a large skillet (mine is 10 1/2 inches in diameter) and heat over medium-high heat. Add the brisket to the skillet and sear on both sides until browned. 
  • Turn off the heat and add the beef broth to the skillet. Cover the skillet with aluminum foil and place the skillet in the oven on the middle rack. Bake for 4 hours.
  • Remove the skillet from the oven and remove the aluminum foil. Place the brisket on a cutting board then cover with the aluminum foil and let the brisket rest for 10 to 15 minutes. 
  • Slice the brisket as thinly as you can. 
  • Assemble gyros. Warm up pita breads first in the microwave for about 30 seconds to 1 minute. Place a pita bread on a piece of parchment paper. Add a few slices of brisket, then top with some tzatziki sauce and finally with Greek salad. Roll up the wrap, enclosing it with the parchment paper. Twist the end of the paper if needed. Repeat with remaining ingredients.

Video

Notes

  1. Although you could use any other slow cooking cut of beef, I recommend beef brisket. Recommended time is 1 hour per pound of meat, so if you have a smaller or larger piece of meat, adjust the cooking time as needed.
  2. You can find Tzatziki recipe here and the Greek salad recipe here.
  3. SLOW COOKER INSTRUCTIONS: Follow the same instructions, but instead of the oven, place the brisket in the slow cooker and cook on low for 8 to 10 hours or high for about 5 hours.
  4. INSTANT POT/PRESSURE COOKER: You can use my Instant Pot Beef Brisket recipe for detailed instructions.
  5. Nutrition: Nutritional information assumes 8 gyros using 4 lb of beef brisket and nutritional information displayed is for 1 gyro.

Nutrition

Serving: 1gyro | Calories: 562kcal | Carbohydrates: 29g | Protein: 53g | Fat: 24g | Saturated Fat: 7g | Cholesterol: 145mg | Sodium: 778mg | Potassium: 1035mg | Fiber: 1g | Sugar: 1g | Vitamin A: 1235IU | Vitamin C: 23.2mg | Calcium: 105mg | Iron: 5.7mg