Place the chicken breasts in a large bowl and cover them with the buttermilk. Make sure the chicken is fully coated in the buttermilk, then cover the bowl with plastic wrap and refrigerate for at least 30 minutes, or up to overnight.
In a shallow dish, combine the flour, garlic powder, paprika, salt, and pepper. Mix well.
Remove the chicken breasts from the buttermilk, shaking off any excess. Dredge the chicken in the flour mixture, shaking off any excess.
Preheat your air fryer to 375°F.
Place the chicken breasts in the air fryer basket in a single layer. Spray the chicken with cooking spray on both sides.
Cook the chicken for 12-15 minutes, or until it is golden brown and cooked through.
In a small saucepan, combine the hot sauce, honey, butter, chili powder, and garlic powder. Cook over low heat, stirring occasionally, until the butter is melted and the mixture is smooth.
Drizzle the hot honey mixture over the chicken breasts in the air fryer basket. Use a spoon to spread the sauce evenly over the chicken.
Return the air fryer basket to the air fryer and cook for an additional 2-3 minutes, or until the sauce is bubbly and caramelized.
Garnish the hot honey chicken with chopped fresh parsley, if desired. Serve hot and enjoy!